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Semaglutide Glycine Cyanocobalamin (Vitamin B12) Suggested Dosing Injections should be administered subcutaneously (under the skin) one time weekly
Randomization and interventions Participants will be randomized in a 1:1 ratio using a random number generator to one of two semaglutide discontinuation strategies: (i) immediate cessation, in which participants will continue their current dose for 16 weeks followed by complete discontinuation, or (ii) gradual dose reduction, in which the semaglutide dosage will be reduced by 25% every 4 weeks until complete discontinuation at week 16
10.1016/j.yexcr.2015.11.024 129
The 2006 clinical study noted this theoretical concern but did not observe pituitary desensitization within its study window
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