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In older patients with DM2 and HTN, an observational study correlated empagliflozin administration with decreased endothelial fragility and OS markers, attributable to reduced mitochondrial ROS production in endothelial cells (Mone et al., 2022)

For example, in pancreatic cancer, the inflammasome component NLRP4 mediates PARPi resistance by promoting NOXO1 expression, which inhibits nuclear translocation of SIRT7, thereby enhancing ROS-induced autophagy and reactivating DDR via reduced H2AX accumulation and impaired BRCA1RAD51 complex formation

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10.1016/j.mito.2021.09.009 250 XieY.KangR.KlionskyD