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Mounjaro (tirzepatide) - European Public Assessment Report (EPAR)

Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]

By educating patients about benefits, honestly disclosing risks, screening for contraindications, and documenting everything clearly, you build trust, ensure safety, and create a defensible record if questions ever arise

When evaluating Cagrilintide vs Retatrutide, this targeted mechanism is what sets Cagrilintide apart