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Thus, the healing of the esophagocutaneous, gastrocutaneous, duodenocutaneous, colocutaneous, vesicovaginalis, and rectovaginalis fistulas, assessed grossly, biomechanically and microscopically means demonstration of the both external and internal fistulas healing and consequently, the realization of the simultaneous healing of different tissues
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They help regulate critical biological functions like metabolism, immune system activity, tissue repair, and collagen production
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