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Maintain a Healthy Diet Maintaining a healthy diet is paramount after discontinuing semaglutide
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In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop
In some brain regions, GLP-1 receptor activation triggers both effects, but in others, like the hippocampus or the ventral tegmental area, food intake reduction occurs without nausea
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