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Psychological problems may include depression, confusion, and difficulty with memory or even dementia
The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo
The STEP 4 trial showed that stopping semaglutide leads to regaining approximately two-thirds of the lost weight within a year
Most people drastically under-eat fiber
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