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While endogenous carriers like extracellular vesicles or biomimetic coatings are designed to minimize immune recognition, the introduction of targeting ligands, synthetic polymers, or residual manufacturing components can provoke unintended inflammatory or foreign body responses, potentially neutralizing the therapeutic effect or causing adverse events

It functions as an electron carrier in cellular respiration and as a substrate for sirtuins (longevity proteins) and PARP enzymes (DNA repair proteins)