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Cell death in cancer cell lines To evaluate the ability of leading candidate proteases to induce cell death via procaspase-1 and gasdermin D cleavage, we stably integrated X(PC) and X(GD), as well as catalytically inactive variants as negative controls, into cancer cell lines under doxycycline-induced expression (Fig
Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis
This way the glutathione enters the bloodstream quickly, providing a continuous antioxidant defence that complements the topical treatment from aox ferulic
ChaC2 may exert a tissue-specific function, promoting the survival of tumor cells in specific contexts (50,81,82)
