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Be willing to adjust your approach based on results
The insulin sensitivity advantage for tirzepatide is larger than weight loss alone explains (Diabetes, Obesity and Metabolism, 2025), which suggests the GIP component does real metabolic work beyond appetite suppression
The concern is theoretical but not dismissible over multi-year use
The present invention provides a pharmaceutical composition comprising semaglutide or a salt thereof, a bioavailability improver, and sustained-release microspheres made of a biodegradable polymer, exhibiting high bioavailability and stable drug release characteristics over a long period of time, and a pharmaceutical composition comprising semaglutide or a salt thereof and sustained-release microspheres made of a biodegradable polymer, exhibiting safe drug release characteristics with high drug content and low initial release, and a method for producing the sustained-release microspheres
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