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baseline characteristics of patients
Once inside acidic lysosomes, the protonatable groups within the micelle core induce a proton-sponge effect, causing osmotic swelling and subsequent vesicle rupture that enables the efficient cytosolic deposition of co-delivered chemotherapeutics like doxorubicin and paclitaxel [27]
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Also, PDSS2 suppressed the concentrations of different CoQ proteins (not CoQ3 and CoQ8A) that can be detected in cybrids consisting of the pathogenic mtDNA A8344G mutation or in 143B cells treated with carbonyl cyanide p-trifluoro-methoxyphenyl hydrazone (FCCP), which is consistent with our previous results for CoQ5 (Yen et al., 2011, 2016)
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