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Without adequate B12, homocysteine levels rise, and elevated homocysteine is neurotoxic, potentially causing direct damage to nerve cells and blood vessels that supply nerves

The retatrutide dosing protocol reflects this triple mechanism

The standard schedule is a starting point, not a strict rule The 2024 NICE guideline NG239 on B12 deficiency in over 16s makes an important point: the optimal route, dose and frequency of B12 replacement have never been firmly established, and have often followed custom and historical practice

The PICOs elements were defined as follows: P (Participants): subjects of any age diagnosed with Vitamin B12 deficiency