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This study examined the roles of oxidative stress, mitochondrial-associated apoptosis, and the pregnane X receptor (PXR)CYP3A4 axis in ATO-induced hepatic changes, and evaluated whether coenzyme Q10 (CoQ10) could modulate these effects depending on administration timing
The production of lactate increases during the process of IRI, and lactate serves as a crucial indicator for assessing the severity of such injury
The results demonstrated a very strong accumulation of ROS inside the hypoxic cancer cells upon treatment with NP4 but a poor ROS accumulation upon preincubation with NAC and subsequent treatment with NP4 (flow cytometry plots: Fig
10.1038/s43856-025-00787-w 105 KlenJ.DolanV
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