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The effect of OVX over mitochondrial functions appears to be related to changes in the fatty acid profile of the mitochondria membrane, where cardiolipin is reduced and more exposed to peroxidation ( DNA Repair When DNA is exposed to ROS, it induces an oxidative base modification that could result in transcriptional mutagenesis (Lindahl, 1993), two processes that leads to genomic instability and cell death (Rodier et al., 2009)

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Tumor redox heterogeneity, variations in intracellular GSH levels, and discrepancies between in vitro and in vivo redox environments make precise prediction of therapeutic activation difficult

Identification of PAD2 as a -glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis