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*What the study uncovered:* Researchers isolated three previously unknown diterpene esters caffaldehydes A, B & C from roasted Coffea arabica These compounds showed potent -glucosidase inhibition, exceeding that of acarbose, a standard therapy for post-prandial hyperglycemia H/C NMR, HPLC, and LC-MS/MS molecular networking enabled identification of both major and trace bioactive molecules Molecular clustering revealed additional structurally related compounds, emphasizing the biochemical complexity created during roasting

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