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These benefits appear to reflect both improvements in traditional risk factors - weight, blood pressure, lipid profiles, glycemic control - and potentially direct cardioprotective effects mediated by GLP-1 receptors expressed in cardiomyocytes and vascular endothelium
Saxagliptin also improves -cell function, increases postprandial insulin secretion and reduces postprandial glucagon secretion
Healthcare providers play a crucial role in monitoring patients for these potential adverse effects and in providing guidance on managing side effects should they arise
Some patients are better served by branded Mounjaro or Zepbound, particularly those with insurance coverage or significant comorbidities
