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(6) When experimenting with the peptide, the investigators apparently recorded lower readings of biochemical markers associated with inflammation, among them indicators of neutrophil buildup, leukotriene B4, and thromboxane B2 within inflamed cell cultures

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26 For instance, the pentadecapeptide could dose-dependently reduce the release of leukotriene B 4 in human blood stimulated by A23187

The elimination of gut bacteria with antibiotics canceled out metformins ability to reduce glucose levels in mice fed a high-fat diet (Shin et al., 2014), highlighting the importance of gut bacteria in how metformin works