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Activation of GLP-1R also increases intracellular Ca 2+ through Ca 2+ release from the endoplasmic reticulum (ER) via the inositol 1,4,5 triphosphate receptors activated by PKA and the ryanodine receptors activated by Epac2 (9)
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Upon release, Nrf2 translocates to the nucleus where it can bind to the antioxidant response element (ARE) located in the promoter region of genes coding for antioxidant enzymes and scavengers
This characteristic suggests that the combination of DHA and astaxanthin could be interesting to enhance and prolong the tanning effect, by combining the immediate coloring action of DHA and the natural stimulation of tanning by astaxanthin
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