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Hepoxilins have pro-inflammatory properties in the skin, especially in psoriatic lesions, but they are anti-inflammatory in neutrophils
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Low levels of potentially toxic oxygen metabolites are physiologically generated in cells and tissues during oxidative phosphorylation.10 The resulting moderate levels of ROS play an integral role in the modulation of several physiological functions of the cell, including gene expression, signal transduction, and defense against invading pathogens
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