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In vivo treatment with fexaramine, an intestine-restricted FXR agonist, results in less weight gain, lower insulin resistance, decreased hepatic steatosis and increased beiging of adipose tissue in diet-induced obese (DIO) mice 38 , these beneficial effects being dependent on gut microbiota and BA/TGR5 signaling 39,40
J.BrayP.FoyerC
"The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro"
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