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Neuroscience Letters 486 (1): 38-42
Through the analysis of numerous in vivo and in vitro studies aimed at determining the mechanisms by which GLP-1 enhances insulin secretion in individuals with normal glucose tolerance or T2DM, two main intracellular mechanisms underlying the incretin effect have emerged
Discussion Despite the eligibility of many patients with cardiovascular disease and overweight or obesity for GLP-1 receptor agonists, the overall incidence of first-time prescribing and dispensing of liraglutide, semaglutide, and tirzepatide was low across the board during the study period
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