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Despite the development of derivatives like N-acetylcysteine amide and N-acetylcysteine ethyl ester which offer improved cell uptake efficiency, bioavailability and antioxidant performance compared to NAC, their application potential for bone tissue engineering warrant further exploration due to the reduced oxidative stability and limited ability to counteract cysteine toxicity ( This review undertook a comprehensive literature search encompassing the areas of NAC and bone tissue engineering

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