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Accompanying symptoms frequently include: Nausea and vomiting that does not relieve the pain Fever and general malaise Abdominal tenderness and distension Rapid pulse and signs of dehydration In severe cases, jaundice (yellowing of the skin or eyes) may occur if the bile duct is affected It is important to distinguish pancreatitis from the common gastrointestinal side effects of Rybelsus, such as nausea, vomiting, and abdominal discomfort, which are usually mild to moderate, transient, and improve with continued use or dose adjustment