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Here is what the committee decided, what the vote means, what still needs to happen, and how the current gray market fits into the conversation
Semaglutide is a revolutionary GLP-1 receptor agonist that was originally developed for patients with Type 2 diabetes, but when providers and pharmaceutical developers noticed how much weight their patients were losing, they began to study semaglutide exclusively for weight loss
Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
Shank2 knockout mice (e67 KO) exhibit decreased expression levels of Gabra2 and GABA receptor-mediated inhibitory signaling, which can be reversed by treatment with allosteric modulators of GABA-ARs (99, 100)
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