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This effect is thought to be mediated by GLP-1s ability to inhibit the activity of hypothalamic neurons that promote hunger and to stimulate the activity of neurons that promote satiety
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The high nucleophilicity of the leaving group, which is generally associated with high basicity, was thought to inhibit the release of the leaving group due to the reverse reaction
Yeung TL, Leung CS, Yip KP, Sheng J, Vien L, Bover LC, et al
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