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A molecular medicine report suggests that TMAO promotes p65 NF-B subunit phosphorylation when stimulating macrophages, while hydrogen sulfide inhibits this process by upregulating silent information regulator 1 (SIRT1) (a negative regulator of NF-B) (109)
Because SCFA production depends on microbiome and diet, GLP-1 medications alone cannot rebuild this pathway
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Christen said she advises GLP-1 users to choose foods with less than 10 grams of fat per serving because fat can worsen symptoms like nausea and acid reflux
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