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It also does not let anyone promise zero risk, particularly for the rare medullary type, which is why the contraindication remains firmly in place
Generally, transitions between GLP-1 agonists can be done without a washout period, though starting the new medication at a lower dose and titrating up is standard practice regardless of what you were taking before
Dosing protocols are not standardized
Microbiota-driven ACh dysregulation is validated in inflammatory bowel disease (IBD) models: Dysbiosis-induced choline deficiency is reversed by cytidine diphosphate (CDP)-choline supplementation, which upregulates choline transporter (ChT1), acetylcholinesterase (AChE), and 7 nicotinic acetylcholine receptor (7nAChR) expression to restore neurotransmission (Vernino et al., 2000)
