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The visceral fatinflammationlipotoxicity axis further alters the ovarian microenvironment
For instance, mitochondrial pyruvate carrier 1 (MPC1) knockout promotes the accumulation of lactate and the subsequent lactylation of fatty acid synthase (FASN) at K673, which further inhibits FASN activity and reduces lipid accumulation
This review examines the link between diabetes and neurodegenerative diseases, explores the effects of antidiabetic agents on neurodegeneration, provides a concise overview of the GLP-1 pathway, and discusses both preclinical and clinical trial outcomes of GLP-1RAs for neurodegenerative diseases, including their effects on cognition in AD and PD
The GLP-1 analog Lira has been shown to have similar effects on cholesterol metabolism with GLP-1 [74]
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