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DiNicolantonio, J., Lavie, C., Fares, H., Menezes, A., & OKeefe, J
Treatment adjustments may include dose optimization, switching to oral semaglutide for improved compliance, or transitioning to tirzepatide (which activates both GLP-1 and GIP receptors for broader appetite suppression)
Although GLP-1 RAs have demonstrated efficacy even without structured behavioral support, their broader therapeutic potentialparticularly regarding long-term behavior change, psychological stabilization, and sustained weight lossmay be most effectively realized when embedded within a biopsychosocial framework
Focus on staying hydrated, eating simple, balanced meals, and letting your body settle into the routine
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