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long-term safety unknown
The expected 18 O incorporation ratio for stochastic incorporation of 47.4% was calculated from the H 2 18 O content before addition of Pt GSTF8
For preclinical tissue models, stronger evidence would require standardized injury models, blinded outcome assessment, histological confirmation, functional endpoints, and comparison against appropriate positive and negative controls
But the side effect patterns differ between oral and injectable formulations, primarily due to route-specific factors and bioavailability differences
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