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The latter is the metabolic crossroads where the products of fatty acid beta oxidation and glucose metabolism through glycolysis can enter the tricarboxylic acid cycle (or Krebs cycle)
The formation of the necrosome followed by the phosphorylation, activation and translocation of mixed-lineage kinase domain-like pseudokinase (MLKL) to the plasma membrane, results in membrane permeabilization and subsequent cell death
Week six marks the end of the purging window
