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The combined effects can produce excessive sedation or unpredictable interactions

The FoxO transcription factor family, particularly FoxO3a, serves as a major regulator of muscle proteolysis 35

The FDA placed it in 503A Category 2 ("may present significant safety risks") in 2023, effectively barring compounding pharmacies from using it, then removed it from that category in April 2026 after nominators withdrew their submission, without adding it to the approved Category 1 compounding list