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Moreover, this approach supports improved reproducibility between cell-based assays and animal models, simplified chronic exposure modeling, scalable comparative screening, and stronger alignment with physiologically based pharmacokinetic simulation frameworks used in translational pharmacology
Topology and paramaterisation files for the -Glu-FA are available in Zenodo [ MD trajectories are available in Zenodo [ Source data files for gels are available within the Supplementary Information file included with this manuscript
Those achieving good results with acceptable side effects have little reason to change
Therefore, its unknown whether its necessary to cycle DSIP
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