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Compared with ADCs, PDCs exhibit better tumor penetration because of their small molecular weight, lower systemic exposure (owing to rapid clearance from the body), lower risk of immunogenicity and liver damage, and easier and cheaper production methods
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Mita, M
265,294,295 The proposed mechanisms involve the activation of the renin-angiotensin system, inflammatory responses, oxidative stress, vascular smooth muscle cell proliferation, and insulin resistance
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