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Blockade of the reninangiotensin system improves cerebral microcirculatory perfusion in diabetic hypertensive rats
Invest 129 (2), 546555
By inhibiting NNMT, 5-Amino-1MQ increases cellular SAM and NAD+ levels, enhances NAD+ salvage pathway flux, activates SIRT-1, boosts oxidative phosphorylation (OXPHOS), and influences cellular energy homeostasis and epigenetic modifications
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