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KEAP1-NRF2 system as a potential therapeutic target in ALS The presence in ALS of increased levels of OS markers and impaired antioxidant defense in the brain and peripheral tissues [25] together with the central role of NRF2 in inducing target genes to counteract OS [272] make the KEAP1-NRF2 system a suitable therapeutic target for drugs and small molecules

Adding to this is the fact that the bodys ability to make GSH naturally declines with age

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Overall, targeting iron acquisition mechanisms represents a powerful, fungus-specific therapeutic direction with multiple avenues for innovation