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Dosing typically combines semaglutide 2.4mg weekly with cagrilintide 2.4mg weekly, though research protocols vary
In REDEFINE 1, cagrilintide 2.4 mg alone over 68 weeks produced a 11.5% mean body-weight change versus 3.0% with placebo (treatment-policy estimand) roughly half the combinations 20.4%
There are though some patients who want to use higher doses and more frequent injections than recommended in NICE guidelines
doi: 10.3390/molecules28217345
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