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These factors extend the network of DAMPs signaling beyond the classical receptors and can further modulate immune cell responses in the postoperative period (for example, IL-33 can drive type 2 immunity and might aid in resolution of injury, whereas HMGB1 sustains inflammation and also promotes immunosuppression in late phases) ( In summary, the perioperative innate immune response is heavily influenced by mtDAMPs release
doi: 10.1016/j.cmet.2020.10.011 26 GaoMMonianPQuadriNRamasamyRJiangX
The amido-imidazopyridine core of dHTC1 inserts into the acetyllysine-binding channel of ENL and makes canonical contacts with F28, H56, H59, S58 and Y78 (Extended Data Fig
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