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Laboratory investigations analyze kinase activation profiles, cytoskeletal remodeling signals, and endocrine-mediated regulatory cascades relevant to peripheral tissue adaptation processes
Godinho JR1
Enzyme Activation: cAMP activates protein kinase A, which phosphorylates hormone-sensitive lipase and perilipin proteins surrounding lipid droplets
In order to demonstrate that the 127 gene signature is related to regional emphysema severity within individuals and not to differences between donors and COPD patients or to differences in levels of emphysema between COPD patients, we repeated the same statistical analysis while only including the five COPD patients with emphysema and standardizing the Lm measurements within each patient core to a mean of zero and a standard deviation of one (Z-score)
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