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Type II Diabetes Patients: NAION risks increased from 1.8% in non-semaglutide users to 8.9% in semaglutide users , representing a 710% increased absolute risk
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Phe 28 of GLP-1 is critical for binding of GLP-1 to GLP-1R and interacts with Leu 32* , Thr 35 *, Val 36 * and Trp 39 *
In response, CMS has proposed a reinterpretation of the statutory exclusion, distinguishing between drugs used for weight loss and those used for the treatment of obesity. This shift would allow Part D and state Medicaid coverage for anti-obesity medications (AOMs) prescribed specifically for obesity
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