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For the SURPASS-CVOT emulation (tirzepatide vs dulaglutide), the hazard ratio for MACE was 0.83 (95% CI, 0.691.01) compared with 0.92 (95% CI, 0.831.01) in the trial, satisfying all concordance criteria
If your TDEE is low and a 12.5% deficit would put your target below 1,200 kcal for women or 1,500 kcal for men, the calculator raises it back to that minimum
PlexusDx semaglutide injections are $189/mo month-to-month, or from $149/mo on the 6-month plan, with no membership fees and HSA/FSA eligibility
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