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In addition, impaired GPx4 expression in peripheral blood monocytes was shown to be a biomarker of increased risk of breast cancer [111]
The most successful strategy toward obtaining GSH overproducing strains was classical selection which resulted in GSH contents of 35 % [14]
Isabella, R
These include potential immunogenicity, undefined long-term biosafety profiles of novel nanomaterials, suboptimal drug loading/release kinetics, limited penetration into the invasive tumor margin, and overcoming the immunosuppressive/hypoxic/acidic TME
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