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For example, activation of transient receptor potential ankyrin 1 (TRPA1) induces Ca influx, promoting calmodulin-dependent protein kinase II (CaMKII) phosphorylation, and Nrf2 nuclear translocation, which upregulates GPX4 to inhibit ferroptosis in high-glucose-exposed endothelial cells, thereby improving cell migration, proliferation, and tube formation to enhance diabetic wound healing [87]
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It is part of a new class of incretin-based medications and functions as a triple agonist, unlike its peers like tirzepatide, which act only as dual agonists
Semaglutide works by mimicking the effects of the glucagon-like peptide-1 (GLP-1) that targets areas in the brain which regulate appetite and food intake
