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5 Counseling Patients on GLP-1s and Pregnancy Prevention Dr Manuel counsels all patients to use an effective form of contraception before starting a GLP-1, as the use of these medications is contraindicated in pregnancy due to limited human safety data and evidence of fetal harm in animal studies. If a patient wishes to become pregnant, she recommends GLP-1 discontinuation 1 to 3 months (depending on the drugs pharmacokinetics) prior to attempting to conceive

22, 2025, and previous reporting by The Associated Press

It is made for adults with obesity, or adults who are overweight with at least one weight related medical condition, to support weight loss and help keep the weight off when prescribed by a healthcare professional

New England Journal of Medicine 2022;387:205216