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By doing so, they not only identified differences in brain-region-specific proteomes between the two cell types but also revealed distinctions in signaling phosphoproteins and cytokines derived from neurons and astrocytes [120]

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Overall, scientific efforts over the past twenty years have shed light on the behavior of meningococcus within the host cell and have supported a model in which, after internalization by the host cell, the meningococcus is able to avoid lysosomal killing by cleaving LAMP1 through IgA protease, and to escape from the internalization vacuole through the C-terminal hemolytic domain of HrpA, reaching the cell cytosol

The cytotoxic effects of these copper compounds on HaCaT cells were observed to be concentration-dependent and time-dependent at concentrations 580 M and 5800 M