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The primary function of hepatic insulin signaling is to decrease HGP by repressing gluconeogenesis mediated by the Akt-induced phosphorylation of forkhead box O1 (FOXO1) [15], which excludes FOXO1 from the nucleus, and thus, prevents the transcriptional activations of gluconeogenic gene expressions, such as glucose-6-phosphatase (G6PC) and phosphoenolpyruvate carboxylase (PEPCK) [15,16]

Selective serotonin reuptake inhibitors (SSRIs), particularly fluoxetine at higher doses, have shown modest efficacy in reducing binge frequency, though they are not specifically licensed for this indication

Never share your pen with others, even if you change the needle

Restrained eating is a tendency to deliberately and consciously restrict food intake to control body weight, despite feelings of hunger