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A large real-world study in patients with peripheral artery disease (PAD) and type 2 diabetes found that GLP-1 therapy was associated with: Fewer hospitalizations Lower rates of lower-limb amputation Reduced need for peripheral revascularization Improved overall survival over 5 years Interestingly, rates of major cardiovascular events, stroke, myocardial infarction, and kidney outcomes were comparable to those seen with metformin
The peptide does not work through a single receptor but rather through simultaneous modulation of multiple healing pathways
Together, they allow researchers to study the amplified, pulsatile release of endogenous GH through complementary signaling pathways
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