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A 2016 review and analysis of randomized controlled trials found that a 90% diosmin preparation significantly reduced leg and ankle edema and lower leg pain (Martinez-Zapata 2016)
Although the pregnancy rate is lower than with in vitro fertilization and intracytoplasmic sperm injection, intrauterine insemination is often recommended first (when feasible) due to its lower invasiveness and cost
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Experimental and Therapeutic Medicine
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