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However, the rising prevalence of depression in the general population is coupled with an increasing number of patients who do not respond to antidepressant therapy, underlining the need to identify underlying factors to enable early detection and intervention, especially in high-risk groups [498]

Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells

Blood tests may show increased bilirubin, alkaline phosphatase, GGT, ALT, AST, or white blood cells when biliary obstruction or inflammation is present

Remarkably, scrambled-injected Trkb Penk -KO mice developed the expected hyperlocomotor phenotype, whereas Trkb Penk -KO mice injected with Gsto2 -shRNA showed no significant difference in performance compared to control mice at all ages analysed (Fig