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Moreover, their capacity to modulate the tumor microenvironment and deliver therapeutic cargo, such as microRNA (miRNAs) or chemotherapeutic agents, positions them as promising candidates for targeted therapy [15, 16]
Furthermore, this novel concept suggests that the GLP-1 analog could spare the pasireotide-induced decrease in endogenous GLP-1 concentrations and recover insulin secretion suppressed by pasireotide through GLP-1R-Gs activation counteracting the SSTRs-Gi axis
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