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10 minutes is the standard duration

Two types of medications for ulcers and gastric reflux proton-pump inhibitors, such as omeprazole (Prilosec) and lansoprazole (Prevacid), and H2 blockers like cimetidine (Tagamet), famotidine (Pepcid), and ranitidine (Zantac) inhibit the release of stomach acid necessary to free dietary vitamin B12

It helps protect cells against the effects of oxidative stress from dietary and environmental free radicals, and those resulting from normal metabolic processes.* Glutathione also serves as a key factor in proper detoxification.* Recommended Use: Take 1 mL (approximately 2 pumps) and hold in mouth for 30 seconds before swallowing or as directed by your health-care practitioner